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Follistatin-344 (FS-344) is a 344-amino-acid isoform of a naturally occurring human glycoprotein that binds and neutralizes myostatin (a protein that limits muscle growth) and activins. By blocking these inhibitors, it removes the natural "brakes" on skeletal muscle development.
• Injectable vs. Gene Therapy: While an injectable "follistatin peptide" is sold online or in performance markets as a research chemical, controlled human clinical data exist only for gene therapy (such as AAV-mediated or plasmid delivery evaluated in small studies for muscular dystrophies or inclusion body myositis). There are no published, controlled human trials proving that injected Follistatin-344 peptide builds muscle in humans.
• WADA Ban: Myostatin-binding proteins, including follistatin, are strictly prohibited in sports at all times by the World Anti-Doping Agency (WADA).
Potential Risks & Concerns
• Unregulated Growth & Off-Target Effects: Inhibiting myostatin and activin pathways can impact tissue remodeling, fibrosis, cardiac and tendon adaptation, and inflammation.
• Pharmacokinetics: Native follistatin is a large glycoprotein with short clearance times in circulation, meaning simple peptide injections do not replicate the sustained local expression achieved in experimental gene-therapy models