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Selank is a synthetic seven-amino-acid peptide (heptapeptide) developed in Russia as an anxiolytic (anti-anxiety) and nootropic drug.
What Selank Is & How It Works
• Structure: It is a synthetic analog of the natural immune-modulating peptide tuftsin, extended with a Pro-Gly-Pro tail for stability.
• Mechanism: It modulates GABAergic signaling, influences monoamine neurotransmitters and serotonin metabolism, inhibits enkephalin-degrading enzymes, and upregulates brain-derived neurotrophic factor (BDNF).
• Administration: It is most commonly used as an intranasal spray, though subcutaneous injection is also practiced.
Potential Benefits
• Anxiety & Stress: Reduces generalized anxiety and emotional reactivity without causing the heavy sedation, cognitive dulling, or physical dependence linked to benzodiazepines.
• Cognition & Focus: Supports mental clarity, memory formation, and learning processes under stress.
• Immune Support: Inherits immunomodulatory properties from tuftsin, helping balance cytokine production and immune response.