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Melanotan-2 acetate (MT-2) is a synthetic cyclic heptapeptide analog of α-melanocyte-stimulating hormone (α-MSH).
Key Characteristics & Mechanism
• Chemical Profile: An acetate salt of a lactam-bridged peptide with the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 and a molecular weight of roughly 1024.2 g/mol.
• Receptor Activity: Acts as a non-selective melanocortin receptor agonist targeting MC1R, MC3R, MC4R, and MC5R.
• Biological Effects: Stimulates skin pigmentation/melanogenesis (via MC1R), can reduce appetite and cause weight loss (via MC4R), and influences sexual arousal or erectile activity (via central nervous system pathways).
• Side Effects: Common and serious adverse effects include severe nausea, vomiting, facial flushing, spontaneous or prolonged erections (priapism), fatigue, and the darkening or proliferation of moles and freckles, which complicates monitoring for melanoma