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LL-37 is a natural, 37-amino-acid human antimicrobial peptide derived from the precursor protein cathelicidin (encoded by the CAMP gene). It acts as a primary component of the innate immune system.
What LL-37 Does
• Antimicrobial Activity: Its positive charge allows it to directly disrupt and break down the cell membranes of bacteria, viruses, fungi, and biofilms.
• Immune Modulation: It regulates inflammation, recruits immune cells to sites of infection or injury, and interacts with nucleic acids.
• Tissue Repair: Research shows it plays a role in skin and mucosal wound healing.
• Research Market Only: Products found online or in wellness circles are typically sold strictly as "research chemicals" or "gray-market" peptides.
• Lack of Human Trials: While its biology is well-documented in laboratory (preclinical) and animal studies, there are no large-scale, controlled human clinical trials proving the safety or effectiveness of self-administered LL-37.
• Context-Dependent Risks: LL-37 can be pro-inflammatory or anti-inflammatory depending on the tissue environment. Preclinical studies have linked abnormal or overexpressed LL-37 activity to autoimmune and inflammatory conditions (such as psoriasis, lupus, and rheumatoid arthritis) as well as potential roles in neuroinflammatory pathways